Siber Solutions offers an CF interface to the Mapscript API via the SWIG / Java API. Now you can ask things like createMap. But also manipulte the layers (setLayerData) in the mapfile the way you want them (in stead of using %var%-variables in the url-request).
Read more at the mapserver wiki
Or download instantly at http://www.sibern.com.au/index.cfm/spid/1_8.cfm
Notice that the latest mapserver is compiled for java 1.5, ColdFusion needs java 1.4.
